Bronchial Vascular Remodeling in Asthma and COPD by Aili Lazaar

By Aili Lazaar

Responding to the expansion of study within the box during the last decade, this ebook brings jointly top investigators with services in pulmonology, pathology, and developmental biology to elucidate the mechanisms that keep an eye on the advance of bronchial vascular home improvement in bronchial asthma and COPD, in addition to discover the pathophysiological approaches that could impression the formula of latest healing techniques for those stipulations.

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J Clin Endocrinol Metab 1994; 79:316–322. 24. Ferrara N, Carver-Moore K, Chen H, et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature (London) 1996; 380:439–442. 25. Carmeliet P, Ferreira V, Breier G, et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature (London) 1996; 380:435–439. 26. Fong GH, Rossant J, Gertsenstein M, Breitman ML. Role of the flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium.

The allergic response also increases vascular permeability permitting the leakage of albumin into the airways, as shown in guinea pigs (117). Chronic Bronchitis, Infection, and Emphysema A variety of species, including rodents, and farm animals, and agents, such as noxious gases, smoke microbes, and drugs, have been used to produce experimental chronic bronchitis (118). The bronchial circulation is increased especially in bronchiectasis (119,120). Local chronic inflammation and pulmonary vascular obstruction both play a pathogenetic role in increasing bronchial vascularity.

5. Magno M. Comparative anatomy of the tracheobronchial circulation. Eur Respir J Suppl 1990; 12:557s–562s. 6. Boyden EA. The developing bronchial arteries in a fetus of the 12th week. Am J Anat 1970; 129a:357–368. 7. Fishman AP. Pulmonary Diseases and Disorders. New York: McGraw Hill, 1980:400. 8. Song JW, Im YS, Park JH, Yeon KM, Han MG. Hypertrophied bronchial artery at thin-section CT in patients with bronchiectasis: correlation with CT angiographic findings. Radiology 1998; 208:187–191. 9.

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