Blood Transfusion in Clinical Practice by P. Kochhar

By P. Kochhar

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This method is recommended only for patients above 20 kg . Besides that, this technique may be accompanied by hemodilution, allowed for patients with hematocrit above 35%. The blood is replaced, using crystalloid fluids to lower hematocrit to 25%, recommended for patients above 1 year old, because of the presence of fetal hemoglobin in neonates. Thus, this technique can be used shortly before surgery. During the intraoperative, the self-transfusion can be performed using machines that reutilize the lost blood on surgery.

However, a Canadian study reported an increased risk of death in cardiac surgery patients treated with aprotinin compared with tranexamic acid and aminocaproic acid and this led to the market suspension of this drug(Fergusson 2008). 7 Antifibrinolytic drugs (Tranexamic acid and aminocaproic acid) These inhibit fibrinolysis by binding to the lysine-binding sites of plasminogen to fibrin. They have been used in TKR patients who have had their operations under tourniquet control. In this situation, local fibrinolytic activity may be enhanced and may cause postoperative bleeding on release of the tourniquet (Murphy 1993; Petaja 1987).

Schved, J. , et al. (2009). Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach. Blood, Vol. 113, No. 21, pp. 5298-5303. , Todd, G. , & Pardoe, G. I. (1974). A study of the serological behaviour and nature of the anti-B-P-Pk activity of Salmonidae roe protectins. Vox Sanguinis, Vol. 26, No. 2, pp. 176-188. , & Sturli, A. (1902). Über die Isoagglutinie im Serum gesunder und kranker Menschen. Münchener Medizinische Wochenschrift, Vol.

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