By Dimitris Tousoulis, Christodoulos Stefanadis
The institution of specific and trustworthy biomarker checks for the early levels of heart problems is of serious significance and will be the cornerstone within the prevention of destiny heart problems (CVD). additionally, a few biomarkers may supply vital details about the pathogenesis of CVD or seem to be important in probability stratification, in CVD analysis, or in tracking treatment; many others may be hazard components themselves, representing as a result power pursuits of treatment. the right biomarker must have the next features: hugely delicate, particular, reliable. Read more...
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Gu et al. examined the association between circulating cathepsin S and cystatin C and coronary plaque morphology (Gu et al. 2009). For this reason, patients with unstable angina (UA) or stable angina (SA) and controls were recruited. Intravascular ultrasound (IVUS) was used to evaluate plaque morphology, whereas plasma cathepsin S and cystatin C were measured. It was concluded that plasma cathepsin S and cystatin C increased significantly in UA patients. In angina patients, higher plasma cathepsin S may suggest the presence of vulnerable plaque, and higher plasma cystatin C may be a clue for larger atherosclerotic coronary plaque.
PAI-1 was positively and independently correlated with BMI and waist-to-hip ratio, and negatively with contraception. Factor VIIc and PAI-1 were correlated with cholesterol and triglycerides, and fibrinogen was weakly correlated with LDL-cholesterol. 01). 57 - NS). There was no significant case/control difference for factor VIIc and PAI-1. These results support the hypothesis that fibrinogen is a transmissible risk factor of coronary artery disease in males. The role of fibrin in premature atherosclerosis was examined in a group of young, post-myocardial infarction patients with angiographic-proven CAD and in healthy volunteers matched for age and sex (Collet et al.