By Malo, Jean-Luc
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Additional resources for Asthma in the Workplace, Fourth Edition
Clin Exp Allergy 2011; 41: 497–504. 92. Chan-Yeung M. Fate of occupational asthma. A follow-up study of patients with occupational asthma due to western red cedar (Thuja plicata). Am Rev Respir Dis 1977; 116: 1023–9. 93. Chan-Yeung M, Lam S, Koerner S. Clinical features and natural history of occupational asthma due to western red cedar (Thuja plicata). Am J Med 1982; 72: 411–15. 94. Malo J-L, Cartier A, Ghezzo H, et al. Patterns of improvement of spirometry, bronchial hyperresponsiveness, and specific IgE antibody levels after cessation of exposure in occupational asthma caused by snow-crab processing.
This can be further divided into internal validity, concerning validity of inferences pertaining to the source population, and external validity, concerning validity pertaining to people outside the source population. The latter is also called generalizability. When studying a causal effect of exposure on a disease/health outcome, internal validity is considered a prerequisite for external validity. It is critical to recognize potential sources of bias and their influence on the interpretation of the results.
Fifth, questionnaires administered by trained physicians have variable sensitivity and specificity in predicting asthma or OA (49–52). Finally, subjects may overreport or underreport their symptoms depending on the circumstances in which the questionnaire is being administered. 3, it can be seen that the proportion of workers proven to be suffering from OA by specific challenge tests or by peak flow rate recording varies in different studies, ranging from 2% to 16% of workers who were considered to have OA using the questionnaire.