Applications of Toxicogenomic Technologies to Predictive by National Research Council, Division on Earth and Life

By National Research Council, Division on Earth and Life Studies, Board on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology

The hot box of toxicogenomics offers a probably robust set of instruments to raised comprehend the future health results of exposures to toxicants within the surroundings. on the request of the nationwide Institute of Environmental healthiness Sciences, the nationwide examine Council assembled a committee to spot some great benefits of toxicogenomics, the demanding situations to attaining them, and power methods to overcoming such demanding situations. The document concludes that understanding the opportunity of toxicogenomics to enhance public future health judgements would require a concerted attempt to generate information, utilize latest facts, and examine info in new ways--an attempt requiring investment, interagency coordination, and information administration thoughts.

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This includes the generation of new toxicogenomic data from humans and animals for a number of compounds for which other types of data already exist as well as the consolidation of existing data. Every effort should be made to leverage existing research studies and infrastructure (such as those of the National Toxicology Program) to collect samples and data that can be used for toxicogenomic analyses. 3. Creation of a centralized national biorepository for human clinical and epidemiologic samples, building on existing efforts.

They serve as general reference maps but do not yet reflect individual variations, including SNPs and groups of SNP alleles (haplotypes), that account for the individual genetic variation underlying different responses to toxic chemical and environmental factors. This section describes technologies for sequencing, for analyzing genotype variation, and for analyzing epigenetic modifications. As technology continues to advance, so will the analyses of genome variations and their roles in humans’ different responses to chemicals and other environmental factors.

13 Introduction As medical science has progressed, so have the tools used to assess animal toxicity. For example, more sensitive diagnostic and monitoring tools have been used to assess organ function, including tools to detect altered heart rhythms, brain activity, and changes in hormone levels as well as to analyze changes visible by electron microscopy. Most notable, however, are the contributions of chemistry, cell and molecular biology, and genetics in detecting adverse effects and identifying cellular and molecular targets of toxicants.

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