By Johannes Ring
Anaphylaxis is the main dramatic and most likely life-threatening manifestation of an immediate-type allergic reaction response. even if recognized for over a hundred years, it nonetheless poses many unresolved questions, and its useful administration and acute remedy are frequently extra empiric in nature than evidence-based. during this booklet, a multidisciplinary staff of specialists overview the cutting-edge within the pathophysiology, epidemiology, analysis and scientific symptomatology of anaphylaxis. Its etiology with reference to varied elicitors akin to insect venoms, radiocontrast media, analgesics, normal and native anesthetics is tested intimately. ultimately, therapy modalities for anaphylaxis are mentioned either for acute reactions and as basic administration options for sufferers in danger. supplying thorough and updated assurance of this usually underestimated challenge, this booklet is of curiosity not just to allergologists and immunologists, but in addition to all physicians and affected sufferers.
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Additional info for Anaphylaxis (Chemical Immunology and Allergy, Vol. 95)
Among many possible food allergens which may account for exercise-induced anaphylaxis, it has been shown recently that the allergenic component ω–5 gliadin from wheat is a frequent cause . As this 14 Worm sensitization can now be measured by determination of specific IgE, the diagnostic workup for this clinical entity has been significantly improved . These data suggest that due to an increase of food allergy and in particular tree nut and peanut sensitization, the risk for anaphylaxis has been increased at the same time.
Nevertheless, at the slowly developing adaptive immunity site, antigen specificity in an evolved response of both T and B lymphocytes takes part. T lymphocytes are responsible for cell-mediated immune responses, where B lymphocytes are for humoral immune responses . Exosomes are vesicles of 30–100 nm produced by inward budding of endosomal compartments and are released by a range of different cell types. Exosomes from APCs carry immunorelevant molecules like MHC class I and II and costimulatory molecules and thus are suggested to have a role in immune modulation.
J Emerg Med 2004;27:371–377. Epidemiology of Anaphylaxis 4 Smit DV, Cameron PA, Rainer TH: Anaphylaxis presentation in a emergency department in Hong Kong: incidence and predictors of biphasic reactions. J Emerg Med 2005;28:381–388. 5 Kiratiseavee S, Ranesg S: Evaluation of pediatric patients admitted with adverse food reactions to an inner-city pediatric ED. J Allergy Clin Immunol 2007;119:S114. 19 6 Mulla ZD, Simon MR: Hospitalizations for anaphylaxis in Florida: epidemiologic analysis of a population-based dataset.