Advances in neuroregulation and neuroprotection by Collin, Catherine

By Collin, Catherine

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The results indicate a possible participation of oxidative stress in the neuropathology of PD patients, especially during a crisis, when the metabolites are highly increased, and point to the use of antioxidant drugs as a possible adjuvant therapy in such situations to improve the neurological status of the patients and to prevent sequelae. All of the vitamin B12 or cobalamin in nature is of microbial origin. Cobalamin is a large polar molecule that must be bound to specialized transport proteins to gain entry into cells.

Di Paolo, R. and Uitti, R. J. (1996). Early detection of Parkinson's disease. Implication for treatment, Drug Aging 9, 159-168. Drummond, J. T. and Methews, R. G. (1994). Nitrous oxide degradation by Cobalamin dependent synthase: Characterization of reactants and products in the inactivation reaction, Biochemistry 33, 3732-3741. Grefen, C. R. (1992). The neostriatal mosiac: multiple levels of compartmental organization, Trend NeuroscL 15, 133-139. German, D. C , Manaye, K. K, White, C. , et al.

05 taken as the level of significance in differences between groups. RESULTS Figure 1 shows the results for the latex bead Phagocytic Index (PI) of peritoneal macrophages from the two groups (basal and stressed) of BALB/c mice incubated with the different concentrations of melatonin (Fig. 1A) or corticosterone (Fig. IB) used in this in vitro study. One observes that the melatonin stimulated the macrophages' capacity to ingest antigens independently of the origin of the macrophages. The maximum stimulation was for basal animal macrophages incubated with the higher melatonin concentration.

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