By Gianfranco Donelli (eds.)
The Advances in Microbiology, Infectious ailments and Public well-being sequence will offer microbiologists, hygienists, epidemiologists and infectious illnesses experts with well-chosen contributed volumes containing up to date info within the components of easy and utilized microbiology regarding proper matters for public future health, together with bacterial, fungal and parasitic infections, zoonoses and anthropozoonoses, environmental and nutrition microbiology.
The expanding hazard of the multidrug-resistant microorganisms and the similar host immune reaction, the recent concepts for the therapy of biofilm-based, acute and protracted microbial infections, in addition to the advance of recent vaccines and extra efficacious antimicrobial medicinal drugs to avoid and deal with human and animal infections should be additionally reviewed during this sequence within the mild of the newest achievements in those fields.
certain awareness might be dedicated to the short diffusion all over the world of the hot findings of the main complex translational researches performed within the varied fields of microbiological sciences, with the purpose to advertise a urged validation and move at medical point of the main promising experimental results.
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Extra resources for Advances in Microbiology, Infectious Diseases and Public Health: Volume 4
2015). Moreover, several probiotic products with Lactobacillus spp. strains that are intrinsically resistant to the above-mentioned antimicrobials can be used for balance of intestinal microbiota during antibacterial therapy. Furthermore, we illustrate schematically (Fig. 14) the complex safety studies on the six putative Lactobacillus spp. strains from the 38 M. Mikelsaar et al. Fig. 14 Development of a safe and efficacious probiotic product Legend: The step-by-step testing was performed including in vitro assays, experimental animal studies, a volunteer safety trial, and a registered clinical efficacy trial, including ethics committee approval, randomization and double blinding of participants for placebo and treatment, defining primary and secondary outcomes for efficacy confirmation, and drawing the preliminary health claim for EFSA acceptance Human Microbiota Biobank (Acronym: HUMB registration number: 977) (Koll et al.
2012a). 1 Host Specificity (Mice, Humans) of Probiotics for Abundance of Intestinal Indigenous Lactobacilli For understanding the impact of probiotic bacteria on the composition of gut microbiota, it is important to rely on their colonization ability and the possibility of increasing the abundance of lactobacilli. The question arises of whether the choice should be a strain of human origin or some environmental good antagonist. In various 34 M. Mikelsaar et al. Table 5 Prevalence of L. fermentum species in fecal samples after consumption of the probiotic strain L.
The strain ME-3 produces some cationic peptides, has a suitable lectin profile for competitive adhesion to the epithelium (Annuk et al. 2001), and some immunogenic properties, as assessed in animal experiments (Truusalu et al. 2008; 2010). 7, produced by strain ME-3 in microaerobic MRS medium, achieving the first rank among about 30 tested strains of Lactobacillus species. This result shows that strain ME-3 can manage with compounds both to suppress antagonists and/or initiate signaling using several pathways.