By F. Lang, M. Ritter, H. Völkl, D. Häussinger (auth.), Prof. Dr. Florian Lang, Prof. Dr. Dieter Häussinger (eds.)
One of the necessities for survival is the power of cells to take care of their quantity. therefore, through the process evolution cells have "learned" a number of ideas to accomplish quantity homeostasis. This quantity regulatory equipment comprises law of either, mobile metabolism and mobile shipping and is exploited by way of hormones and transmitters to manage cellularfunction. This ebook to illustrates the advanced interaction of mobile quantity regulatory mechanisms and mobile functionality in various tissues. despite the fact that, our wisdom remains to be faraway from being conclusive, and the current number of stories is assumed to foster additional experimental efforts to resolve the position of cellphone quantity within the built-in functionality of cells.
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Extra info for Advances in Comparative and Environmental Physiology: Interaction of Cell Volume and Cell Function
This gradient and, accordingly, the degree of cell swelling are modified by hormones and the nutritional state in a complex way. Their action not only involves effects on the expression of plasma membrane transport systems and the electrochemical Na + gradient as a driving force for Na + -coupled transport, but also alterations of intracellular amino acid metabolism. For example in livers from rats fed insulin, which is known to stimulate amino acid transport via system A (Le Cam and Freychet 1978), enhances the glycine-induced cell swelling (Hallbrucker et al.
Am J Physiol 250: F953-F962 Lang F, Defregger M, Paulmichl M (1986b) Apparent chloride conductance of subconfluent Madin Darby canine kidney cells. Pfliigers Arch Eur J Physiol 407: 158-162 26 F. Lang et al. Lang F, Paulmichl M, Volkl H, Gstrein E, Friedrich F (1987) Electrophysiology of cell volume regulation. In: Kovacevic Z, Guder WG (eds) Molecular physiology: biochemical aspects of kidney function. de Gruyter, Berlin, pp 133-139 Lang F, Oberleithner H, Kolb HA, Paulmichl M, Volkl H, Wang W (1988) Interaction of intracellular pH and cell membrane potential.
3. Effect of glucagon and insulin on liver cell volume. In the absence of hormones cell volume was 559 ± 71ll/g liver. (vom Dahl et al. 1991c) stimulates amino acid uptake. Whereas this tends to swell the cell, glucagon in fact shrinks the cells due to a glucagon-induced net K+ release and dissipation of the amino acid concentration gradient across the plasma membrane due to a glucagon-induced stimulation of amino acid breakdown.