By Jan Lotvall
content material: Similarities and transformations within the pathophysiology of bronchial asthma and COPD / Christian Virchow --
Glucocorticoids : pharmacology and mechanisms / Peter Barnes --
Inhaled corticosteroids? scientific results in bronchial asthma and COPD / Paul O'Byrne --
LABAS : pharmacology, mechanisms and interplay with anti inflammatory remedies / Gary Anderson --
lengthy and ultra-long performing beta-2-agonists / Mario Cazzola --
the protection of long-acting beta agonists and the improvement of blend treatments for bronchial asthma and protracted obstructive pulmonary disorder / Eugene Bleecker --
Inhaled blend treatment with glucocorticoids and long-acting beta-2-agonists in bronchial asthma and COPD, present and destiny views / Jan Lotvall --
Novel anti inflammatory remedies for bronchial asthma and COPD / Ian Adcock --
Novel biologicals by myself and together in bronchial asthma and hypersensitivity / William Busse --
Anti-infective remedies in bronchial asthma and COPD / Jonathan D.R. Macintyre & Sebastian L. Johnston --
lengthy performing muscarinic antagonists in bronchial asthma and COPD / Denis O'Donnell --
Phosphodiesterase inhibitors in obstructive lung ailment / Jan Lotvall --
organic remedies in improvement for COPD / Riccardo Polosa --
Triple therapy?, within the administration of persistent obstructive lung sickness (COPD). the price of mixture remedy with inhaled steroid, lengthy appearing anticholinergicbronchodilator and lengthy performing beta 2 agonist bronchodilator in COPD / Ronald Dahl.
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Extra resources for Advances in combination therapy for asthma and COPD
53. 54. 55. 56. 57. 58. 59. 60. 61. 62. 63. 64. 65. 66. 67. 68. September 8, 2011 0:41 Printer Name: Yet to Come CHAPTER 2 prednisolone to inhibit JUN N-terminal kinase phosphorylation. J Allergy Clin Immunol 1999; 104:565–74. Matthews JG, Ito K, Barnes PJ, Adcock IM. Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients. J Allergy Clin Immunol 2004;113:1100–8. Galigniana MD, Piwien-Pilipuk G, Assreuy J. Inhibition of glucocorticoid receptor binding by nitric oxide.
Lewis-Tufﬁn LJ, Cidlowski JA. The physiology of human glucocorticoid receptor beta (hGRbeta) and glucocorticoid resistance. Ann N Y Acad Sci 2006;1069:1–9. 19. Ismaili N, Garabedian MJ. Modulation of glucocorticoid receptor function via phosphorylation. Ann N Y Acad Sci 2004;1024:86–101. 20. Dostert A, Heinzel T. Negative glucocorticoid receptor response elements and their role in glucocorticoid action. Curr Pharm Des 2004;10:2807–16. 21. Kurihara I, Shibata H, Suzuki T, et al. Expression and regulation of nuclear receptor coactivators in glucocorticoid action.
1 Pharmacological properties of inhaled corticosteroids. 7 11 21 Ͻ1 23 Ͻ1 Ͻ1 88 80 90 71 NA 99 NA, not available. = 1. a Dexamethasone Beclometasone dipropionate (BDP) Since 1972, BDP has been available by inhalation for the treatment of asthma. It has all of the properties of the other lipophilic corticosteroids; however, because of its early development, very little pharmacokinetic information is available on this compound. Initially, BDP is biotransformed into its active metabolite, beclometasone monopropionate, in the liver, but further metabolism of beclometasone monopropionate appears to be slower than that of the newer, topically active corticosteroids.