Adalat® in the Asian Pacific Region by Y. Nakamura, H. Miyashita, O. Iimura, K. Ueda, T. Sugimoto,

By Y. Nakamura, H. Miyashita, O. Iimura, K. Ueda, T. Sugimoto, Y. Toyama (auth.), Prof.Dr. David T. Kelly (eds.)

These are the lawsuits of the 3rd Asian Pacific Adalat Symposium. the 1st was once held in Tokyo in 1982 and the second one in Sydney in 1985. We have been honoured that the overdue Dr. Sukaman and his colleagues have been in a position to host this 3rd symposium in Jakarta. This assembly was once designed to give a contribution to and to advertise overseas collaboration in cardiovascular study, and to aid advertise extra wisdom and figuring out in regards to the therapy of vascular illness within the Asian Pacific region. Nifedipine was once initially investigated within the mid-1960s via Prof. Fleckenstein. His first effects confirmed this drug was once a robust calcium antagonist which altered excitation contraction. at present, there has been a speedy improvement of information in regards to the pathophysiology of ischaemic center ailment, and hence the $64000 pharmacological paintings on calcium antagonists akin to nifedipine paralleled and complimented the more recent knowing of coronary body structure in guy. very quickly so much remedy was once designed to lessen myocardial oxygen intake and demand.

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Mair TW (1972) Subendocardial distribution of coronary blood flow and the effect of antianginal drugs. Circ Res 30:621 39. Lipscomb K, Gould KL (1975) Mechanism of the effect of coronary artery stenosis on coronary flow in the dog. Am Heart J 89:60 40. Kavanagh T, Shepard RJ, Chisholn AW, Quereshi S, Kennedy J (1979) Prognostic indexes for patients with ischemic heart disease enrolled in an exercise-centered rehabilitation program. Am J Cardiol44:1225 41. Sami H, Kraemer H, Debusk RF (1979) The prognostic significance of serial exercise testing after myocardial infarction.

C. 3. E. 4. AE. 5. e. 6. B. 7. D. 8. F. L. 9. " 10. U. 11. J. A 12. T. 13. R. 14. R. P. 15. Z. 16. M. L. 17. K. " 18. C'" 19. " 20. e. 21. AR. 22. a 23. S. 24. b M F F F M F F M M M M M M M F M M M F M M M M F Sex C, Control; N, nifedipine. a Insignificant angiography. 0 C 3 b Angiography with positive ergonovine test. 0 0 C 0 Stage Table 4. ,~ > 0- ~ ? 00 MEAN STSEGMENT DEPRESSION (mm) 14 13 7 3 I 14 14 14 STAGES; 0 14 14 DURING EXERCISE 12 III 6 IV 4 2 min 14 AFTER EXERCISE 5 min 14 8 min 14 --~--l_-l __ J//-----t---l-_l-_l 14 Fig.

In these studies the effect of ischemia on ventricular filling has been the one of the most important subjects. The LVPF demonstrated by radionuclide angiography in patients with coronary artery disease has been shown to be diminished, and the abnormality of the early ventricular filling has been reported to be independent of left ventricular systolic function and the presence or absence of previous myocardial infarction (Bonow et al. 1981). However, a recent study by Carroll and coworkers in which left cine ventriculography during exercise was analyzed showed that early left ventricular filling was augmented during exercise in patients with ischemia as well as in patients without ischemia.

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