Acquired Neuromuscular Disorders: Pathogenesis, Diagnosis by Corrado Angelini

By Corrado Angelini

This booklet presents cutting-edge info at the pathogenesis, prognosis, and therapy of various inflammatory, autoimmune, and idiopathic neuromuscular issues. the outlet part discusses the differential analysis of obtained myopathies in accordance with medical, electrophysiological, muscle biopsy, and serological standards, with distinct specialise in the position of electromyography and antibody checking out. all the correct scientific entities is then mentioned intimately, the assurance together with, for instance, myasthenia gravis, polymyositis, immune-mediated neuropathies, multifocal motor neuropathies, amyotrophic lateral sclerosis, paraneoplastic neuropathies, and diabetic polyneuropathy. transparent suggestions is supplied on presently on hand remedies, with descriptions of the most recent advances in physiotherapy, drug remedy, and respiration care. different gains of this clinically orientated publication are the inclusion of many illustrative case shows and contributions by way of foreign authors from prime centers.

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Extra info for Acquired Neuromuscular Disorders: Pathogenesis, Diagnosis and Treatment

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Motor control. American Physiological Society, Bethesda, pp 2345–2412 3. Henneman E, Mendel LM (1981) Functional organization of motor neuron pool and its inputs. In: Brooks VB (ed) Handbook of physiology, The nervous system. Vol. 2. Motor control. American Physiological Society, Bethesda, pp 423–507 4. Preston DC, Shapiro BE (2005) Repetitive nerve stimulation. In: Preston DC, Shapiro BE (eds) Electromyography and neuromuscular disorders: clinical- electrophysiologic correlations, 2nd edn. Elsevier, Philadelphia, pp 65–75 5.

Neurology83(2):113–117. 0000000000000566 58. Dalakas MC (2011) Advances in the diagnosis, pathogenesis and treatment of CIDP. Nat Rev Neurol 7(9):1–11 59. Berger M, McCallus DE, Lin CS-Y (2013) Rapid and reversible responses to IVIG in autoimmune neuromuscular diseases suggest mechanisms of action involving competition with functionally important autoantibodies. J Peripher Nerv Syst 296:275–296 60. Miura Y, Devaux JJ, Fukami Y et al (2015) Contactin 1 IgG4 associates to chronic inflammatory demyelinating polyneuropathy with sensory ataxia.

However, the degree of facilitation is usually less marked than that observed in LEMS (>60 %). Moreover, facilitation may be initially absent in adult in whom facilitation may require more prolonged high-frequency stimulation (up to 20 s). Postactivation exhaustion is not seen in botulism [6]. Highlights Motor unit potentials in myopathies are generally shortened and of polyphasic shape. However, the most frequent finding of needle EMG in myopathies is the increased variability of MUPs. Some fibrillation potentials can be found in most myopathies, but they are more frequent in sIBM, acute necrotizing myopathy, and polymyositis.

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